Abstract:Aimed at the selection of the substitute herbicides of atrazine in corn, field studies were conducted in Gongzhuling and Langfang, located in northeast spring corn region and in Huang-Huai-Hai summer corn region, respectively, to study the herbicide mixture containing isoxaflutole and thiencarbazone-methyl for weed control in corn as pre-emergence treatments in 2016 to 2017. Weed spectrum, control efficacy, corn yield and the injuries to the following crops, wheat, soybean, peanut, rape, spinach were evaluated in the two locations. All treatments controlled the regional dominant weeds Echinochloa crus-galli, Setaria viridis, Eleusine indica, Digitaria ciliaris, Amaranthus retroflexus, Portulaca oleracea, Abutilon theophrasti, Cephalanoplos segetum about 95% 40-45 days after application when the herbicide mixture was used 141.75-283.5 g ai/ha. Corn yield was increased by 103.9%-120.3% and 19.3%-25% comparing with the untreated plots in Gongzhuling and Langfang, respectively, and all the tested following crops were not affected by the carryover of the mixture in the soil.